Government and social trust vs. hotel response efficacy: A protection motivation perspective on hotel stay intention during the COVID-19 pandemic

Based on protection motivation theory (PMT), this study conceptualizes a research framework to explain and examine customer intentions regarding hotel stays during the COVID-19 pandemic. Data were collected from 700 U.S. consumers via a crowdsourcing website in July 2020. Structural equation modeling was used to analyze the collected data for testing proposed hypotheses. The analytical results showed that the level of threat perceived by customers significantly reduced their intention to stay at a hotel. On the contrary, individual customer response efficacy significantly enhanced their intention to stay at a hotel. Additionally, both government and social trust, as well as hotel response efficacy, were found to significantly increase hotel stay intention by mediating the effects of threat perception and individual response efficacy. To the best of our knowledge, this study is one of the first attempts to apply PMT to explain customer hotel stay intentions during the COVID-19 pandemic.     

瑞舒伐他汀与替格瑞洛联合用药方案治疗非ST段抬高型急性冠脉综合征患者的临床效果及不良反应

目的探讨瑞舒伐他汀与替格瑞洛联合用药方案治疗非ST段抬高型急性冠脉综合征(ACS)患者的临床效果及不良反应。方法选取2018年1月至2019年7月沈阳积水潭医院收治的70例非ST段抬高型ACS患者作为研究对象,依据随机数字表法分为对照组和观察组,每组35例。对照组采用替格瑞洛治疗,观察组采用瑞舒伐他汀与替格瑞洛联合用药方案治疗,比较两组临床疗效、心肌损伤指标、炎症介质水平、不良反应发生率。结果观察组治疗有效率高于对照组,差异有统计学意义(P<0.05);观察组肌酸激酶同工酶、肌钙蛋白水平低于对照组,差异有统计学意义(P<0.05);观察组炎症介质水平、不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论瑞舒伐他汀与替格瑞洛联合用药方案治疗非ST段抬高型ACS临床效果显著,不仅可以改善临床相关指标、心肌损伤,还可减轻炎症反应,且不良反应发生率低。     

中药方剂浸浴联合外用钙泊三醇倍他米松软膏治疗寻常性银屑病患者的临床效果

目的探讨中药方剂浸浴联合外用钙泊三醇倍他米松软膏治疗寻常性银屑病患者的临床效果。方法选取2018年2月至2019年4月于沈阳市第七人民医院就诊的寻常性银屑病患者114例作为研究对象,以随机数字表法将其分为观察组和对照组,每组57例。对照组患者外用钙泊三醇倍他米松软膏进行治疗,观察组患者通过中药方剂浸浴联合外用钙泊三醇倍他米松软膏治疗。比较两组患者临床疗效、银屑病面积严重程度指数(PASI)评分以及不良反应发生率。结果观察组患者治疗有效率为82.46%,显著高于对照组的63.16%(P<0.05)。两组患者治疗2周、4周后的PASI评分均显著低于治疗前(P<0.05);观察组患者治疗2周、4周后的PASI评分均显著低于对照组(P<0.05)。观察组患者的不良反应发生率为14.04%,低于对照组的21.05%,但差异无统计学意义(P>0.05)。结论中药方剂浸浴联合外用钙泊三醇倍他米松软膏治疗寻常性银屑病能有效改善患者的临床症状,效果显著,且不良反应少。     

建筑施工企业效绩评价研究

针对一般竞争性状态的大型建筑施工企业,从出资人角度出发,通过对企业效绩问题的深入研究,探索一套适合我国国情的建筑施工企业效绩评价体系,建立和完善科学规范的建筑施工企业效绩评价体系,引导企业树立正确的经营理念。     

A Socio‐Psychological Perspective on Team Ambidexterity: The Contingency Role of Supportive Leadership Behaviours

In addressing the notion of team ambidexterity, we propose that socio‐psychological factors (i.e., team cohesion and team efficacy) may help team members to resolve paradoxical challenges and to combine exploratory and exploitative learning efforts. In addition, we theorize that senior executives may play an important role in facilitating the emergence of ambidexterity at lower hierarchical levels. In doing so, we develop a multilevel contingency framework and propose that the effectiveness of teams to achieve ambidexterity is contingent upon supportive leadership behaviours at the organizational‐level. Using multilevel, multisource, and temporally separated data on 87 teams within 37 high‐tech and pharmaceutical firms, we not only reveal how team cohesion and efficacy may matter for the emergence of team ambidexterity but also show that the effectiveness of supportive leadership behaviours from senior executives varies across cohesive and efficacious teams.     

有激情的员工更能创新吗

员工创新绩效是衡量企业创新能力的重要标准。以创造力交互作用观为理论框架,从认知视角考察员工和谐型激情通过创造力自我效能感对创新绩效的作用机制及相应的情境机制。对492份问卷分析发现：和谐型激情对员工创新绩效有正向预测作用;创造力自我效能感中介了和谐型激情与创新绩效的关系;创新氛围感知既调节了和谐型激情与创造力自我效能感的关系,又调节了创造力自我效能感在和谐型激情与创新绩效之间的中介作用。研究结果揭示了员工情感与认知对提高创新绩效的重要意义。     

Matching-adjusted indirect comparison of adalimumab vs etanercept and infliximab for the treatment of psoriatic arthritis

Abstract

Objectives:

No head-to-head trial has compared the efficacy of adalimumab vs etanercept and infliximab for psoriatic arthritis (PsA). This study implements a matching-adjusted indirect comparison technique to address that gap.

Methods:

Patient-level data from a placebo-controlled trial of adalimumab (ADEPT) were re-weighted to match average baseline characteristics from pivotal published trials of etanercept and infliximab. ADEPT patients were re-weighted by odds of enrollment in comparator trials, estimated using logistic regression. Matched-on characteristics included PsA duration, age, gender, severity, active psoriasis, and concomitant treatment. After matching, placebo-adjusted treatment arms were compared at weeks 12 (or 14) and 24. Outcomes included ACR20/50/70, PsARC, HAQ, and modified TSS. PASI50/75/90 were compared for patients with active psoriasis. Cost per responder (CPR) was assessed in the US and Germany using matching-adjusted end-points and drug list prices. Statistical significance was assessed using weighted t-tests.

Results:

After matching, adalimumab-treated patients had greater placebo-adjusted rates of ACR70 and PASI50/75/90 at week 24 compared with etanercept (all p?<?0.05). Adalimumab patients had a higher placebo-adjusted rate of ACR70 than infliximab at week 14 (p?=?0.034). Adalimumab treatment had lower CPR for ACR70 and PASI50/75/90 compared with etanercept at week 24, in both the US and Germany (all p?<?0.02). Adalimumab had lower CPR than infliximab for all outcomes at week 24 (all p?<?0.05).

Conclusion:

Adalimumab is associated with higher ACR70 and PASI50/75/90 response rates than etanercept at week 24 and a higher ACR70 response rate than infliximab at week 14. Adalimumab has significant advantages over etanercept and infliximab in CPR across multiple end-points.

Key limitations:

The matching-adjusted indirect comparison method cannot account for unobserved differences in patient characteristics across trials, and only a head-to-head randomized clinical trial can fully avoid the limitations of indirect comparisons. CPR findings are limited to the US and German markets, and may not be generalizable to other markets with different relative pricing.     

收入倍增实现有效性及路径分析——基于GM模型预测研究

十八大提出的"收入倍增计划"是否能实现,怎样更好实现是我国今后要面临的主要问题。应用灰色预测模型预测未来十年间的城乡居民的实际人均收入,可以发现城镇居民收入倍增计划能够较好实现,但农村居民收入倍增实现困难。造成这种现象的原因除了模型本身的缺陷外,还有"政策红利"未来临及制度依赖等因素。文章认为应通过充分挖掘政策红利,打破制度依赖等手段促进收入倍增的更好实现。     

公共部门员工自我效能、职业生涯复原力对职业生涯满意度的影响--基于职业生涯韧性中介效应的实证检验

基于整体和系统的角度,本文构建了职业生涯自我效能、职业生涯复原力、职业生涯韧性与职业生涯满意度关系的整合概念模型,并运用经验数据给予了实证检验。研究结果表明,公共部门员工职业生涯自我效能、职业生涯复原力、职业生涯韧性对职业生涯满意度具有显著的正向影响机制,公共部门员工职业生涯韧性对职业生涯自我效能与职业生涯满意度及职业生涯复原力与职业生涯满意度之间的关系具有中介效应。     

我国汽车产业技术赶超的进入成本

本文在对技术赶超进入成本理论进行探讨的基础上,对我国国内汽车产业技术赶超的进入成本条件及成本效应进行了分析,以期明确国内汽车产业技术赶超的进入成本约束状况。